The Syntaxin 17 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to STX17, and Syntaxin 17. This antibody recognizes Human, Mouse, and Rat antigen. The Syntaxin 17 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Function: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).
Subunit Structure: Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (PubMed:23217709, PubMed:25686604). Interacts with VAMP7 and VTI1B (PubMed:23217709). Probably interacts with BET1, SCFD1 and SEC22B (By similarity). Interacts with PTPN2 and ABL1; involved in STX17 phosphorylation (PubMed:23006999). Interacts with COPB1 (By similarity). Interacts with TMED9 and TMED10; the interaction is direct (PubMed:21545355). Interacts with ATG14 (PubMed:25686604).
Post-translational Modifications: Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum (By similarity).
Similarity: Belongs to the syntaxin family